Hydroxypropyl beta-cyclodextrin

Product Introduction

Hydroxypropyl-β-cyclodextrin is a hydrophilic derivative formed by the condensation of β-cyclodextrin and 1, 2-propylene oxide. After being encapsulated with drugs, hydroxypropyl -β-cyclodextrin has the effect of enhancing solubility and stability, and thus can be used as a carrier, diluent, etc. Hydroxypropyl -β -cyclodextrin is widely used in fields such as food, medicine, cosmetics, agriculture and analytical chemistry.

The products are also classified into: pharmaceutical grade and food grade

Product application

The introduction of hydroxypropyl group breaks the intramolecular cyclic hydrogen bond of beta-cyclodextrin, maintaining the cyclodextrin cavity while overcoming the main drawback of poor water solubility of beta-cyclodextrin. It is mainly applied in the food, pharmaceutical and cosmetic industries.

1. In the pharmaceutical industry: Due to its relatively low surface activity and hemolytic activity, as well as its non-irritating effect on muscles, hydroxypropyl beta-cyclodextrin is an ideal solubilizer for injectables and excipient for drugs. It can enhance the water solubility of poorly soluble drugs, increase their stability, improve their bioavailability, reduce the dosage or increase the dosage of the drug, and adjust or control the release rate of the drug. It can be used as a carrier for oral medications, injections, mucosal drug delivery systems (including nasal mucosa, rectum, cornea, etc.), transdermal absorption drug delivery systems, and lipophilic targeted drugs. It can also be used as a protective agent and stabilizer for proteins.

2. Hydroxypropyl -β -cyclodextrin can enhance the stability of drugs. Some medicinal substances will degrade due to exposure to light, heat and oxygen, thereby losing some or even all of their efficacy and failing to meet the requirement of maintaining stable properties within the normal 3 to 5-year drug validity period

3. In the fields of food and spices: Hydroxypropyl beta-cyclodextrin can enhance the stability and long-term effectiveness of nutrient molecules, mask or correct the unpleasant odors and tastes of food nutrient molecules, and improve production processes and product quality. This product has excellent solubility in water. With a degree of substitution of 4 or above, it can be miscible with water in any proportion and also dissolve in 50% ethanol and methanol.

4. In the field of cosmetic raw materials: Hydroxypropyl beta-cyclodextrin is used as a stabilizer, emulsifier, deodorizer, etc. It can reduce the irritation of organic molecules in cosmetics to skin and mucous membrane tissues, enhance the stability of active ingredients, and prevent the volatilization and oxidation of nutrients. It has a certain relative hygroscopicity.